Short name: Gd-DTPA mesoporphyrin, generic name: gadophrin, central moiety: Gd2+
Gadophrin is a substance under development (Bayer Schering Pharma AG) as a positive enhancing myocardium- and necrosis- targeted MRI contrast agent.

See also Metalloporphyrins and Necrosis Avid Contrast Agent.

Short name: Gd-DOTA, generic name: Gadoterate meglumine
Dotarem / [ Artirem® ] A paramagnetic MRI contrast agent for intravenous use. This agent is used as a routine clinical tool to reveal anatomical details in vivo and to detect lesions for diagnosis.

See also Contrast Agents.

Short name: Gd-HP-DO3A, generic name: Gadoteridol injection, chemical compound: Gd-1,4,7-tris(carbonylmethyl)-10-(2'-hydroxypropyl)-1,4,7,10-tetraazacyclododecane
(ProHance®) A nonionic MRI contrast agent with a low molecular weight complex of gadolinium (macrocyclic chelate, which tightly binds the Gd atom).
Gadoteridol does not cross the blood brain barrier. If the barrier is damaged, gadoteridol will penetrate into lesions such as tumors. It also highlights areas of increased vascularity so it has been used to improve the delimitation of lesions elsewhere in the body.
Apart from its paramagnetic effects, gadoteridol has no pharmacological activity in the body. After intravenous injection, most of the dose is excreted unchanged in the urine within 24 hours.

See also Contrast Agents and ProHance®.

Short name: Gd-DTPA-BMEA, generic name: Gadoversetamide
A paramagnetic extracellular MRI contrast agent with positive enhancement. When placed in a magnetic field, gadoversetamide decreases T1 and T2 relaxation times in tissues where it accumulates. At the recommended dose, the effect is primarily on T1 relaxation time, and produces an increase in signal intensity (brightness).

See Contrast Agents and OptiMARK™.

Short name:(Gd-DTPA)n-dextran, central moiety: Gd2+
Gd-DTPA labeled dextran is a substance that has been tested as a blood pool agent (intravascular MRI contrast agent). Dextran is a polysaccharide and has labeled with 15 Gd-DTPA moieties a higher T1 relaxivity than unbound Gd-DTPA, compared with a high safety level.

See also Intravascular Contrast Agents, Blood Pool Agents.